Influence of captopril on human sperm motility parameters in vitro.
- Author:
Hua-Xiong YAO
1
;
Ji-Hong LIU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Angiotensin-Converting Enzyme Inhibitors; pharmacology; Captopril; pharmacology; Cells, Cultured; Dose-Response Relationship, Drug; Humans; Male; Sperm Motility; drug effects; Spermatozoa; cytology; drug effects
- From: National Journal of Andrology 2006;12(5):435-437
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo determine the effects of captopril on human sperm motility in vitro.
METHODSSperm specimens were aseptically obtained by masturbation and prepared by Percoll gradient-centrifugation technique to produce a spermatozoa suspension of high motility from 12 healthy fertile men. The spermatozoa suspension were incubated with captopril at 1:9 ratio of volume at 37 degrees C in vitro, which was administrated at three different concentrations. Measurements were carried out within 5 minutes for all specimens including VAP, VSL, VCL, STR, ALH and progressive motility.
RESULTSWithin 5 minutes, three different concentrations of captopril could change the human spermatozoa motility and forward motile sperm percentage, but captopril did not decrease the other motility parameters, including VSL, VCL and VAP etc. The high concentration group could decrease the VCL more than those of the other two groups and it seemed that the velocity parameters of the middle concentration group were higher than those of the other two groups, but there were no significant difference statistically.
CONCLUSIONIt suggests that captopril can decrease the human spermatozoa motility and forward motile sperm percentage, but it can not directly affect the spermatozoa velocity in vitro.
