Effects of experimental varicocele on the apoptosis of epididymis epithelium and synthesizing function of the epididymis in rats.
- Author:
Yu-gang ZHAO
1
;
Ji ZHOU
;
Xue-jun ZHANG
;
Xiao-wei MEN
;
Rui WANG
;
Fei ZHOU
;
De-hong CHEN
;
Zhi-yun YU
;
Hong-bo SHI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Apoptosis; Epididymis; pathology; Epithelium; pathology; Male; N-Acetylneuraminic Acid; metabolism; Rats; Rats, Sprague-Dawley; Varicocele; metabolism; pathology; alpha-Glucosidases; metabolism
- From: National Journal of Andrology 2006;12(7):619-621
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the relationships of experimental varicocele to the apoptosis of epididymis epithelium and changes of the contents of alpha-1,4-glucosidase and sialic acid from the unilateral epididymis in adolescent rats, and to investigate the effects of varicocele on the unilateral epididymis epithelium.
METHODSExperimental left varicocele models of 16 adult male Sprague-Dawley rats were obtained by partial ligation of the left renal vein. The epididymides were collected for detecting the apoptosis of epididymis epithelium and the contents of alpha-1,4-glucosidase and sialic acid by using spectrophotometry.
RESULTSSeven days after the establishment of the left varicocele model, the index of the apoptosis of the left epididymis epithelium was significantly higher (P < 0.001) and the contents of alpha-1,4-glucosidase and sialic acid significantly lower (P < 0.05, P < 0.005) in the experimental group than in the control.
CONCLUSIONThe results suggest that unilateral varicocele may increase the apoptosis of epididymis epithelium and the contents of alpha-1,4-glucosidase and sialic acid and subsequently affect the synthesizing and secretory function of the epididymis.
