Damage to and protection of sperm DNA.
- Author:
Jie SUN
1
;
An-fang ZHOU
Author Information
1. Department of Basic Theories of Traditional Chinese Medicine, Hubei College of Traditional Chinese Medicine, Wuhan, Hubei 430061, China.
- Publication Type:Journal Article
- MeSH:
Antioxidants;
pharmacology;
DNA Damage;
DNA Repair;
physiology;
Humans;
Male;
Oxidative Stress;
Spermatozoa;
chemistry;
ultrastructure
- From:National Journal of Andrology
2006;12(7):639-646
- CountryChina
- Language:Chinese
-
Abstract:
The damage to sperm DNA is one of the most important causes of male infertility. Some sperm with damaged DNA may escape from the sperm surveillance mechanism and transmit the damage to the offspring. So research on the damage to sperm DNA has become one of the hot spots in reproductive medicine. The factors that would damage sperm DNA include oxidative stress, microelements, reproductive toxic substances, radioactive rays, and so on, while the body depends on the compressed sperm DNA and anti-oxidation system for the protection of the integrity of sperm DNA. Some drugs such as anti-oxidant, black tea extract, etc, may help to improve and rebuild these protective mechanisms.
