CAG repeats of DNA polymerase gamma in Chinese males and relationship of idiopathic male infertility to CAG repeats.

Author: Nan YAO ¹ ; Jun-Feng ZHENG ; Yi-Feng PENG ; Zuo-Xiang LI ; Zuo-Qi PENG ; Xiao-Hua JIN ; Xu MA
Author Information

1. Department of Medical Genetics, Peking Union Medical College, Beijing 100730, China.
Publication Type:Journal Article
MeSH: Adult; Case-Control Studies; China; epidemiology; DNA Polymerase gamma; DNA-Directed DNA Polymerase; genetics; Gene Frequency; Genotype; Humans; Infertility, Male; epidemiology; ethnology; genetics; Male; Polymerase Chain Reaction; Trinucleotide Repeats
From: National Journal of Andrology 2006;12(8):681-688
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo analyze the polymerase gamma(Polg) gene polymorphisms in Chinese idiopathic infertile males and evaluate the correlation of the polymorphisms with male infertility.
METHODSWe conducted a study of Polg CAG repeats in the sperm or blood DNA of 55 asthenospermia patients, 57 oligospermia patients, 34 azoospermia patients, and 104 controls with PCR and GeneScan. Phenotypic data were available in all the subjects, including semen parameters, and clinical profiles.
RESULTSThe frequency of 10/not 10 CAG genotype in asthenospermia patients was higher than in the other groups, but with no significance.
CONCLUSIONOur findings have shown for the first time that there exits an ethnic difference between Chinese and European males in the number of CAG repeats of Polg gene, and that 10/not 10 CAG genotype may affect sperm motility.