Advances in the study of steroidogenic acute regulatory protein.
- Author:
Cao-Ye WANG
1
;
Yu-Bang WANG
Author Information
1. Department of Toxicology, Nanjing Medical University, Nanjing, Jiangsu 210029, China. caoyewang@yahoo.com.cn
- Publication Type:Journal Article
- MeSH:
Animals;
Cholesterol;
metabolism;
Cholesterol Side-Chain Cleavage Enzyme;
metabolism;
Ethisterone;
metabolism;
Gene Expression Regulation;
Humans;
Mice;
Mitochondria;
metabolism;
Phosphoproteins;
genetics;
physiology;
Rats
- From:
National Journal of Andrology
2006;12(8):733-736
- CountryChina
- Language:Chinese
-
Abstract:
The steroidogenic acute regulatory (StAR) protein is an essential component in the regulation of steroid biosynthesis in adrenal and gonadal cells. The StAR protein has a high tissue specificity, located on the mitochondrial membranes of some relative cells. It regulates the transfer of cholesterin from extracellular into intracellular and plays a dominant role in steroidogenic synthesis. Recent studies have also shown that the transcription and expression of StAR are modulated not only through the cAMP-PKA dependent pathway, but also by multiple hormones and cytokines, which contributes to the regulation of cholesterin synthesis.
