Effects of antibiotic and anti-inflammatory treatment on serum PSA and free PSA levels in patients with chronic prostatitis IIIA.
- Author:
Wei WANG
1
;
Wei-lie HU
;
Huai YANG
;
Xiao-fu QIU
;
Chang-zheng ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Anti-Bacterial Agents; therapeutic use; Anti-Inflammatory Agents, Non-Steroidal; therapeutic use; Chronic Disease; Humans; Male; Middle Aged; Prostate-Specific Antigen; blood; Prostatitis; blood; drug therapy
- From:National Journal of Andrology 2006;12(9):787-790
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of antibiotics and a nonsteroidal anti-inflammatory agent on the level of total prostate specific antigen (PSA) and free PSA ratio (F-PSAR) in patients with chronic prostatitis IIIA.
METHODSA total of 228 outpatients diagnosed as with chronic prostatitis III A received 4-week antibiotic and anti-inflammatory treatment. The PSA level and F-PSAR were determined before and after the treatment, and the changes analyzed.
RESULTSSignificant variations were observed in the median PSA concentrations (3.51 microg/L and 2.75 microg/L) and F-PSAR (0.25% and 0.27%) 4 weeks after the treatment. Sixty-five of the patients (28.5%) presented with serum PSA greater than 4 ng/ml, the mean PSA decreased by 32.9%, from 6.24 microg/L before the treatment to 4.58 microg/L 4 weeks after the treatment (P < 0.05), and the serum PSA was normalized in 18 of the 65 patients (27.7%). The median variation of F-PSAR (0.16% and 0.22%) was greater than that of PSA. The variation indexes obtained 4 weeks after the treatment showed no statistical difference from those observed 8 weeks after the treatment.
CONCLUSIONChronic prostatitis IIIA appears to contribute to increased serum PSA levels in some men. Antibiotic and anti-inflammatory treatment could significantly reduce the PSA level and increase F-PSAR.
