Urokinase-type plasminogen activator and urokinase-type plasminogen activator receptor in the seminal plasma and sperm of fertile and oligoasthenozoospermia males.
- Author:
Ling WANG
1
;
Huang-tao GUAN
;
Yong-hong TIAN
;
Cheng-liang XIONG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Case-Control Studies; Enzyme-Linked Immunosorbent Assay; Humans; Male; Oligospermia; physiopathology; Receptors, Cell Surface; metabolism; Receptors, Urokinase Plasminogen Activator; Semen; chemistry; Sperm Motility; Urokinase-Type Plasminogen Activator; metabolism
- From: National Journal of Andrology 2006;12(9):791-793
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo find the difference between the levels of urokinase-type plasminogen activator (uPA) and urokinase-type plasminogen activator receptor(uPAR) in the seminal plasma and sperm of fertile and oligoasthenozoospermia men, and to understand their correlation with male fertility.
METHODSThe levels of uPA in the seminal plasma and sperm of 22 normospermic males and 44 oligoasthenozoospermia patients were measured by ELISA.
RESULTS(1) The average level of uPA in the seminal plasma and sperm of the normospermic group, ([4803.69 +/- 602.78] mU/L) and ([30.29 +/- 3.16] mU/10(6) sperm) were higher than those of the oligoasthenozoospermia group, ([4061.35 +/- 736.23] mU/L), and ([20.51 +/- 4.2] mU/10(6) sperm) (P < 0.01). (2) The average level of uPAR in the sperm of the normospermic group ([12.97 +/- 3.11] mU/10(6) sperm) was significantly higher than that of the oligoasthenozoospermia group, ([6.09 +/- 1.45] mU/10(6) sperm) (P < 0.01). (3) The levels of uPA and uPAR in the sperm and the content of uPA in the seminal plasma were positively correlated with sperm motility and viability.
CONCLUSIONUrokinase-type plasminogen activator is related with male fertility and the levels of uPA and uPAR vary in the seminal plasma and sperm of fertile and oligoasthenozoospermia males.
