Inhibition effect of 6-gingerol on hair growth.
- Author:
Yong MIAO
;
Ya-Bin SUN
;
Wen-Jun WANG
;
Zhi-Dan ZHANG
;
Jin-Dou JIANG
;
Ze-Hua LI
;
Zhi-Qi HU
- Publication Type:Journal Article
- MeSH: Animals; Catechols; pharmacology; Cell Culture Techniques; Cells, Cultured; Fatty Alcohols; pharmacology; Hair; drug effects; growth & development; Hair Follicle; drug effects; growth & development; Humans; Mice; Mice, Inbred C57BL; Plant Extracts; pharmacology; Rats; bcl-2-Associated X Protein; metabolism
- From: Chinese Journal of Plastic Surgery 2013;29(6):448-452
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of 6-gingerol, the main active component of ginger, on hair shaft elongation in vitro and hair growth in vivo.
METHODSFirstly, Hair follicles were co-cultured with 3 different concentration of 6-gingerol for 5 days and hair elongation in three groups was measured. Secondly, The proliferative effect of 6-gingerol on DPCs was measured using MTT assay. Thirdly, the expression of Bcl-2 and Bax in DPCs were measured using Western blotting. In vivo study, the influence of 6-gingerol on hair growth in C57BL/6 rats was measured through topical application of 6-gingerol on the dorsal skin of each animal.
RESULTSThe length of hair shaft in 20 microg/ml 6-Gingerol group (0.50 +/- 0.08 mm) is less than 0 microg/ml (0.66 +/- 0.19) mm and 10 microg/ml (0.64 +/- 0.03) mm 6-Gingerol group (P < 0.05). In cell culture, compared to 0 microg/ml and 5 microg/ml 6-Gingerol, 10 microg/ml 6-Gingerol can significantly inhibited the proliferation of DPCs (P < 0.05). Along with the growth inhibition of DPCs by 6-gingerol, the Bax/Bcl-2 ratio increased obviously. In vivo study, the hair length and density decreased a lot after using 1 mg/ml 6-gingerol.
CONCLUSIONS6-Gingerol can suppress human hair shaft elongation because it has pro-apoptotic effects on DPCs via increasing Bax/Bcl-2 ratio. It might inhibit hair growth by prolonging the telogen stage in vivo.