Anti-gastric ulcer sesquiterpene lactone glycosides from Crepis napifera.
- Author:
Shao-hua WU
1
;
Xiao-dong LUO
;
Yun-bao MA
;
Xiao-jiang HAO
;
Da-gang WU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Anti-Ulcer Agents; chemistry; isolation & purification; pharmacology; therapeutic use; Aspirin; Crepis; chemistry; Disease Models, Animal; Female; Gastric Acid; secretion; Gastric Mucosa; secretion; Male; Molecular Conformation; Molecular Structure; Plant Roots; chemistry; Plants, Medicinal; chemistry; Rats; Rats, Sprague-Dawley; Rats, Wistar; Sesquiterpenes; chemistry; isolation & purification; pharmacology; therapeutic use; Stomach Ulcer; chemically induced; drug therapy
- From: Acta Pharmaceutica Sinica 2002;37(1):33-36
- CountryChina
- Language:Chinese
-
Abstract:
AIMThe anti-gastric ulcer constituents from the roots of Crepis napifera (Franch) Babc (Compositae) were studied.
METHODSSolvent partition, Si gel and Rp-18 column chromatography, crystallization and spectral methods were used to extract, isolate and identify two compounds. The activity of compound 1 was tested on the rat stomach by determining the effect on aspirin-induced gastric lesions and on histamine-stimulated gastric acid secretion.
RESULTSTwo sesquiterpene lactone glycosides, taraxinic acid-1'-O-beta-D-glucopyranoside (1) and 11,13-dihydro-taraxinic acid-1'-O-beta-D-glucopyranoside (2) were obtained. Compound 1 at the dose of 80 mg.kg-1 p.o. inhibited significantly the development of aspirin-induced gastric lesions in the rat and at an i.v. dose of 70 mg.kg-1 did not affect histamine-stimulated gastric acid secretion in the lumen-perfused rat stomach.
CONCLUSIONCompound 1 is the active component of the plant which protects gastric mucosa and exhibits anti-gastric ulcer action.
