Synthesis of 4-, 6- or 7-substituted phenyliminomethylenecoumarins and their anticancer activities.
- Author:
Song XU
1
;
Shi-ping XU
;
Lan-min LI
Author Information
- Publication Type:Journal Article
- MeSH: Antineoplastic Agents; chemical synthesis; chemistry; pharmacology; Carcinoma, Hepatocellular; pathology; Colonic Neoplasms; pathology; Coumarins; chemical synthesis; chemistry; pharmacology; Humans; Imines; chemical synthesis; chemistry; pharmacology; KB Cells; drug effects; Liver Neoplasms; pathology; Molecular Structure; Tumor Cells, Cultured; drug effects
- From: Acta Pharmaceutica Sinica 2002;37(2):113-116
- CountryChina
- Language:Chinese
-
Abstract:
AIMA series of substituted phenyliminomethylenecoumarins derivatives was designed in order to find compounds possessing anticancer activities.
METHODSTitle compounds (1a-b, 2a-b and 3a-q) were synthesized and screened by several anticancer models in vitro.
RESULTSTwenty-one new compounds (1a-b, 2a-b and 3a-q) were synthesized and screened. Structures of the new compunds were determined by MS, HNMR and elemental analysis. Twelve compounds (3c, 3d, 3e, 3f, 3g, 3h, 3j, 3k, 3m, 3o, 3p, 3q) showed inhibitory effects on HCT-8, KB and Bel7402 cell lines in vitro.
CONCLUSIONSome compounds had certain anticancer activities and were worth further studying.
