Regulatory function and expression of rap1gap gene in hematopoietic cells-review.
- Author:
Stella Aprilia IKA
1
;
Xiao-Fei QI
;
Zi-Xing CHEN
Author Information
1. Jiangsu Institute of Hematology, First Hospital, Suzhou University, Suzhou 215006, Jiangsu Province, China.
- Publication Type:Journal Article
- MeSH:
Hematologic Neoplasms;
genetics;
metabolism;
Humans;
Signal Transduction;
rap1 GTP-Binding Proteins;
genetics;
metabolism
- From:
Journal of Experimental Hematology
2009;17(4):1093-1096
- CountryChina
- Language:English
-
Abstract:
Rap1 is a small G protein belonging to the RAS superfamily. Rap1 signalling has effects on cell growth, cell proliferation and involves in regulation of the mitogen activated protein (MAP) kinase or ERK (extracellular signal regulated kinase) cascade. Rap1 will directly activate ERK through B-Raf. B-Raf is a member of Raf family, and presents in neuronal and hematopoietic cells. Oncogenic mutations of gene RAS are most frequent and detected in 20% - 30% of human leukemias and 10% - 15% of MDS cases. The review summarizes the regulatory function of Rap1 in development of hematopoietic cells and effect of Rap1 in hematologic malignancies.
