Reprogramming in origin and development of leukemia stem/progenitor cells.
- Author:
Ke-Fu WU
;
Xiao-Tong MA
- Publication Type:Editorial
- MeSH:
Cell Differentiation;
Cellular Reprogramming;
Humans;
Induced Pluripotent Stem Cells;
Leukemia;
genetics;
Neoplastic Stem Cells;
Stem Cells
- From:
Journal of Experimental Hematology
2009;17(5):1123-1126
- CountryChina
- Language:Chinese
-
Abstract:
The success of yielding induced pluripotent stem (iPS) cells from human somatic cells demonstrates the important role of reprogramming in the formation of stem/progenitor cells and initiates the exploration of the origin of leukemia stem cells. In our previous work, we have found two types of leukemia, bona fide leukemia and non-bona fide leukemia. Different leukemias originate from different leukemia stem/progenitor cells which are critical to the genesis and evolution of leukemia. Bona fide leukemia and non-bona fide leukemia originate from leukemia stem cells and progenitor cells, respectively. Recent research suggests that different types of leukemia are influenced by the reprogramming state of their origin cells.
