Expression of pituitary tumor transforming gene and C-myc gene in patients with multiple myeloma.
- Author:
Da-Qi LI
1
;
Ping CHEN
;
Jian-Hua SHAO
;
Xue-Bin DONG
;
Ya-Li CHANG
;
Hong-Yu ZHAO
;
Ya-Wei ZHOU
Author Information
1. Department of Hematology, Jinan Central Hospital, Affiliated to Shangdong University, Jinan 250013, Shangdong Province, China. ldq9194@126.com
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Case-Control Studies;
Female;
Gene Expression Regulation, Neoplastic;
Humans;
Male;
Middle Aged;
Multiple Myeloma;
genetics;
Neoplasm Proteins;
metabolism;
Proto-Oncogene Proteins c-myc;
metabolism;
RNA, Messenger;
genetics;
Securin;
Young Adult
- From:
Journal of Experimental Hematology
2009;17(5):1238-1241
- CountryChina
- Language:Chinese
-
Abstract:
The study was purposed to explore the expressions of pituitary tumor transforming gene and c-myc gene in patients with multiple myeloma (MM) and its relationship with pathogenesis of MM. Expressions of pituitary tumor transforming gene and c-myc gene mRNA in BMMNC from 33 patients with MM and 10 normal controls were detected by reverse transcriptase-polymerase chain reaction (RT-PCR). The results showed that the expressions of pituitary tumor transforming gene and c-myc gene mRNA were significantly higher in MM patients those that in normal controls (p<0.05). The expression of pituitary tumor transforming gene mRNA was significantly correlated with the expression of c-myc gene (r=0.801, p<0.05). In conclusion, the overexpressions of pituitary tumor transforming gene and c-myc gene may be related to the pathogenesis and progression of MM.
