Nocardial infection after allogeneic hematopoietic stem cell transplantation.
- Author:
Jing LIU
1
;
Mei XUE
;
Hong-Min YAN
;
Zhi-Dong WANG
;
Ling ZHU
;
Li DING
;
Heng-Xiang WANG
Author Information
1. Department of Hematology, Air Force General Hospital, PLA. Beijing 100036, China.
- Publication Type:Case Reports
- MeSH:
Adolescent;
Female;
Hematopoietic Stem Cell Transplantation;
adverse effects;
Humans;
Male;
Middle Aged;
Nocardia Infections;
etiology;
Retrospective Studies;
Transplantation, Homologous
- From:
Journal of Experimental Hematology
2009;17(5):1339-1341
- CountryChina
- Language:Chinese
-
Abstract:
In order to explore the diagnosis and therapeutic effectiveness of nocardiosis after allogenic hematopoietic stem cell transplantation (allo-HSCT), the features of clinical manifestation, laboratory examination and response to TMP-SMZ treatment in two cases of nocardiosis after allo-HSCT were analyzed retrospectively. The result showed that the attack happened to 2 patients at day 15 and 170 after allo-HSCT respectively, displaying fever and chest pain. Chest CT scan indicated bilateral pulmonary tuberculous shadow. Nocardiosis was diagnosed by the culture of sputum, bronchoalveolar lavage (BAL) fluid and pus samples as well. Both of these cases exhibited good response to combined therapy containing TMP-SMZ for half a year. It is concluded that nocardiosis is a rare complication after allo-HSCT, in which pulmonary involvement is commonly observed. The culture of BAL fluid is helpful for its diagnosis and this disease might be sensitive to the treatment of TMP-SMZ-containing regimens.
