A comparative cytogenetic analysis in large scale between adult and childhood patients with acute lymphoblastic leukemia.
- Author:
Xu-Ping LIU
1
;
Xiao-Fan ZHU
;
Jian-Xiang WANG
;
Ying-Chang MI
;
Yao ZOU
;
Yu-Mei CHEN
;
Cheng-Wen LI
;
Yun DAI
;
Shuang QIN
;
Ji-Gang XIAO
;
Fang-Yun XU
;
Jin-Ying GONG
;
Si-Ping WANG
;
Cheng-Long YU
;
Jing FAN
Author Information
1. Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Child;
Child, Preschool;
Chromosome Aberrations;
Cytogenetic Analysis;
Female;
Humans;
Infant;
Infant, Newborn;
Karyotyping;
Male;
Middle Aged;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
genetics;
Sample Size;
Young Adult
- From:
Journal of Experimental Hematology
2009;17(6):1399-1404
- CountryChina
- Language:Chinese
-
Abstract:
This study was purposed to comparatively analyze the cytogenetic characteristics between 566 cases of adult acute lymphoblastic leukemia (aALL) and 586 cases of childhood acute lymphoblastic leukemia (cALL). The cytogenetic analysis of all the patients was performed, and the FISH detection for partial patients was carried out. The result showed that the difference of chromosome abnormality between cALL and aALL was statistically significant. The percentage of abnormal karyotypes in aALL was 62.0%, including mainly t(9;22)(q34;q11), hypodiploidy, hyperdiploidy (47 - 50), abn(6q), abn(9p) and -7, most of which conferring an unfavorable prognosis. The percentage of abnormal karyotypes in cALL was 39.2%, composed mainly of high hyperdiploidy, hypodiploidy, TEL/AML1(+), +8, hyperdiploidy (47 - 50) and +21, etc, most of which conferring a favorable prognosis. The incidences of abnormal karyotypes, total hypodiploidy, total hyperdiploidy (47 - 50), t(9;22)(q34;q11), -7, abn(7q), abn(14q32) and +Ph in aALL were significantly higher than those of cALL (p < 0.05), whereas the incidences of normal karyotype (N), high hyperdiploidy, +8, +21*2 and TEL/AML1(+) in cALL were significantly higher than those of aALL (p < 0.05). 20.5% of aALL were Ph+ aALL, with 63.8% of which being with additional abnormalities, composed mainly of +Ph, -7, i (9q+), 9p-, +8, +21, +X, 6q-, abn(14q32) and +14. In contrast, only 4.4% of cALL were Ph+ aALL, with 42.3% of which being with additional abnormalities, including mainly abn(9p), abn(7p), -7, 17p- and +21. It is concluded that almost every chromosome is involved in the numerical and structural abnormalities and complex karyotypes are common. The significant difference of chromosome abnormality exists between aALL and cALL.
