Antipyretic and antinociceptive activity of Diospyros lotus L. in animals.

Abdur Rauf; Ghias Uddin; Bina S Siddiqui; Naveed Muhammad; Haroon Khan

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Antipyretic and antinociceptive activity of Diospyros lotus L. in animals.

Author: Abdur RAUF ¹ ; Ghias UDDIN ¹ ; Bina S SIDDIQUI ² ; Naveed MUHAMMAD ³ ; Haroon KHAN ⁴
Author Information

1. Institute of Chemical Sciences, University of Peshawar, Peshawar-25120, KPK, Pakistan.
2. H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan.
3. Department of Pharmacy, Hazara University, Havelian Campus, Abbottabbad-22500, Pakistan.
4. Gandhara College of Pharmacy, Gandhara University, Peshawar-25120, KPK, Pakistan.
Publication Type:Journal Article
Keywords: Antinociceptive activities; Antipyretic; Diospyros lotus; Ebenaceae
From:Asian Pacific Journal of Tropical Biomedicine 2014;4(Suppl 1):S382-6
CountryChina
Language:English
Abstract:
OBJECTIVETo evaluate pharmacologically the traditional use of Diospyros lotus as antipyretic and antinociceptive in various animal models.
METHODSIn vivo experimental models were used in this study. Antipyretic activity of extract/fractions was evaluated in brewer's yeast induced hyperthermic mice while antinociceptive activity was studied in acetic acid induced writhing test at 50 and 100 mg/kg i.p.
RESULTSThe crude extract strongly ameliorated the induced pyrexia during various assessment times. Upon fractionation, the antipyretic effects were strongly augmented by the chloroform and ethyl acetate fractions of the plant. However, hexane and butanol fractions were insignificant in their effect as antipyretic. The extract showed marked inhibition on the noxious simulation induced by post acetic acid injection. The effect was strongly supported by other fraction expect hexane.
CONCLUSIONSIn short, our study scientifically validated the traditional use of the plant as antipyretic.