High levels of Zinc-α-2-Glycoprotein among Omani AIDS patients on combined antiretroviral therapy.

Sidgi Syed Anwer Hasson; Mohammed Saeed Al-balushi; Muzna Hamed Al Yahmadi; Juma Zaid Al-busaidi; Elias Antony Said; Mohammed Shafeeq Othman; Talal Abdullah Sallam; Mohammed Ahmad Idris; Ali Abdullah Al-jabri

Return

High levels of Zinc-α-2-Glycoprotein among Omani AIDS patients on combined antiretroviral therapy.

Author: Sidgi Syed Anwer HASSON ¹ ; Mohammed Saeed AL-BALUSHI ¹ ; Muzna Hamed Al YAHMADI ¹ ; Juma Zaid AL-BUSAIDI ¹ ; Elias Antony SAID ¹ ; Mohammed Shafeeq OTHMAN ¹ ; Talal Abdullah SALLAM ² ; Mohammed Ahmad IDRIS ¹ ; Ali Abdullah AL-JABRI ¹
Author Information

1. Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, P.O. Box 35, Muscat, Oman.
2. Department of Community Health, Faculty of Applied Medical Sciences, Al-Baha University, Saudi Arabia.
Publication Type:Journal Article
Keywords: AIDS; Combined antiretroviral therapy; Levels; Oman; Patients; Zinc-α-2-glycoprotein
From:Asian Pacific Journal of Tropical Biomedicine 2014;4(8):610-613
CountryChina
Language:English
Abstract:
OBJECTIVETo investigate the levels of zinc-α-2-glycoprotein (ZAG) among Omani AIDS patients receiving combined antiretroviral therapy (cART).
METHODSA total of 80 Omani AIDS patients (45 males and 35 females), average age of 36 years, who were receiving cART at the Sultan Qaboos University Hospital (SQUH), Muscat, Oman, were tested for the levels of ZAG. In addition, 80 healthy blood donors (46 males and 34 females), average age of 26 years, attending the SQUH Blood Bank, were tested in parallel as a control group. Measurement of the ZAG levels was performed using a competitive enzyme-linked immunosorbent assay and in accordance with the manufacturer's instructions.
RESULTSThe ZAG levels were found to be significantly higher among AIDS patients compared to the healthy individuals (P=0.033). A total of 56 (70%) of the AIDS patients were found to have higher levels of ZAG and 16 (20%) AIDS patients were found to have high ZAG levels, which are significantly (P>0.031) associated with weight loss.
CONCLUSIONSZAG levels are high among Omani AIDS patients on cART and this necessitates the measurement of ZAG on routine basis, as it is associated with weight loss.