Iron-chelating and anti-lipid peroxidation properties of 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) in long-term iron loading β-thalassemic mice.

Kanokwan Kulprachakarn; Nittaya Chansiw; Kanjana Pangjit; Chada Phisalaphong; Suthat Fucharoen; Robert C Hider; Sineenart Santitherakul; Somdet Srichairatanakool

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Iron-chelating and anti-lipid peroxidation properties of 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) in long-term iron loading β-thalassemic mice.

Author: Kanokwan KULPRACHAKARN ¹ ; Nittaya CHANSIW ¹ ; Kanjana PANGJIT ² ; Chada PHISALAPHONG ³ ; Suthat FUCHAROEN ⁴ ; Robert C HIDER ⁵ ; Sineenart SANTITHERAKUL ⁶ ; Somdet SRICHAIRATANAKOOL ¹
Author Information

1. Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
2. College of Medicine and Public Health, Ubon Ratchathani University, Ubon Ratchathani, Thailand.
3. Institute of Research and Development, Government Pharmaceuticals Organization, Ministry of Public Health, Thailand.
4. Thalassemia Research Center, Institute of Molecular Biosciences, Mahidol University Salaya Campus, Nakornprathom, Thailand.
5. Institute of Pharmaceutical Science, King's College London, Franklin-Wilkins Building, London, United Kingdom.
6. Medical Science Research Equipment Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Publication Type:Journal Article
Keywords: Iron chelator; Iron overload; Iron-chelating; Lipid peroxidation; Non-transferrin bound iron; β-thalassemia
From:Asian Pacific Journal of Tropical Biomedicine 2014;4(8):663-668
CountryChina
Language:English
Abstract:
OBJECTIVETo evaluate the iron-chelating properties and free-radical scavenging activities of 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) treatment in chronic iron-loaded β-thalassemic (BKO) mice.
METHODSThe BKO mice were fed with a ferrocene-rich diet and were orally administered with CM1 [50 mg/(kg.day)] for 6 months. Blood levels of non-transferrin bound iron, labile plasma iron, ferritin (Ft) and malondialdehyde were determined.
RESULTSThe BKO mice were fed with an iron diet for 8 months which resulted in iron overload. Interestingly, the mice showed a decrease in the non-transferrin bound iron, labile plasma iron and malondialdehyde levels, but not the Ft levels after continuous CM1 treatment.
CONCLUSIONSCM1 could be an effective oral iron chelator that can reduce iron overload and lipid peroxidation in chronic iron overload β-thalassemic mice.