Short Insulin Tolerance Test Can Determine the Effects of Thiazolidinediones Treatment in Type 2 Diabetes.
10.3349/ymj.2008.49.6.901
- Author:
Mi Young LEE
1
;
Jang Hyun KOH
;
Soo Min NAM
;
Pil Moon JUNG
;
Joong Kyung SUNG
;
Song Yi KIM
;
Jang Yel SHIN
;
Young Goo SHIN
;
Choon Hee CHUNG
Author Information
1. Department of Internal Medicine, 4Institute of Lifelong Health, Yonsei University Wonju College of Medicine, Wonju, Korea. cchung@yonsei.ac.kr
- Publication Type:Original Article
- Keywords:
Thiazolidinediones;
insulin sensitivity;
short insulin tolerance test;
type 2 diabetes
- MeSH:
Aged;
Blood Glucose/metabolism;
Diabetes Mellitus, Type 2/blood/*diagnosis/*drug therapy;
Drug Tolerance;
Female;
Humans;
Hypoglycemic Agents/therapeutic use;
Insulin/diagnostic use;
*Insulin Resistance;
Male;
Middle Aged;
Thiazolidinediones/*therapeutic use
- From:Yonsei Medical Journal
2008;49(6):901-908
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The short insulin tolerance test is a simple and reliable method of estimating insulin sensitivity. This study was designed to compare the insulin sensitizing effects of thiazolidinediones (TZDs) on the degree of insulin resistance, determined by a short insulin tolerance test (Kitt) in type 2 diabetic patients. PATIENTS AND METHODS: Eighty-three subjects (mean age = 57.87 +/- 10.78) with type 2 diabetes mellitus were enrolled and received daily one dose of rosiglitazone (4mg) or pioglitazone (15mg). The mean follow-up duration was 25.39 +/- 9.66 months. We assessed insulin sensitivity using HOMA-IR and the short insulin tolerance test before and after TZDs treatment. RESULTS: When we compared patients' characteristics before and after TZDs treatment, the mean fasting glucose level was significantly decreased (183.27 +/- 55.04 to 137.35 +/- 36.42mg/dL, p < 0.001) and the mean HbA1C level was significantly decreased (9.24 +/- 1.96 to 8.11 +/- 1.39%, p < 0.001). Also, Kitt values were significantly increased (2.03 +/- 1.14 to 2.67 +/- 0.97%/min, p = 0.003), whereas HOMA-IR was significantly decreased (2.98 +/- 0.68 to 1.04 +/- 0.24, p < 0.05). When classifying insulin resistance by Kitt values, insulin resistant subjects' values were increased (< 2.5%/min; 1.51 +/- 0.53%/min to 2.63 +/- 0.88, p < 0.001), whereas the values decreased in insulin sensitive subjects (> or = 2.5%/min; 3.50 +/- 0.75%/min to 2.75 +/- 1.12%/min, p = 0.002). CONCLUSION: The glucose lowering effects of TZDs by improving insulin resistance could be determined by using Kitt. However, Kitt may be a beneficial tool to determine TZDs' effects only when patients' Kitt values are less than 2.5%/min.
