Association of preoperative serum IGF- I concentration with clinicopathological parameters in patients with non-small cell lung cancer.
10.1007/s11596-013-1101-3
- Author:
Sheng-ling FU
1
;
He-xiao TANG
;
Yong-de LIAO
;
Wen-yang JIANG
;
Qin-zi XU
;
Yu DENG
;
Xiang-ning FU
Author Information
1. Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. t0102005@126.com
- Publication Type:Journal Article
- MeSH:
Aged;
Biomarkers, Tumor;
blood;
Carcinoma, Non-Small-Cell Lung;
blood;
diagnosis;
surgery;
China;
Female;
Humans;
Insulin-Like Growth Factor I;
analysis;
Lung Neoplasms;
blood;
diagnosis;
surgery;
Male;
Middle Aged;
Preoperative Period;
Prognosis;
Reproducibility of Results;
Risk Assessment;
Sensitivity and Specificity;
Survival Rate
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2013;33(2):224-227
- CountryChina
- Language:English
-
Abstract:
Insulin-like growth factor-I (IGF-I) is a mitogenic and anti-apoptotic factor. Serum IGF-I concentration is related to some cancer risk and tumor progression. The aim of this research was to study the association of preoperative serum IGF-I concentration with clinicopathological parameters and prognosis of non-small cell lung cancer (NSCLC). Preoperative serum IGF-I concentration was measured in 80 consecutive patients with NSCLC who underwent radical lung cancer resection, and 45 patients with benign pulmonary lesion (BPL) by using enzyme linked immunosorbent assay (ELISA). The results showed that the serum IGF-I concentration was elevated and correlated with clinicopathological parameters and overall survival (OS) in NSCLC patients. Serum IGF-I concentration was significantly higher in patients with NSCLC than in those with BPL. The IGF-I concentrations were significantly higher in NSCLC patients with ≥T2, N1-3, and in IIIA-IV but not in those with
