Intrahepatic cholestasis of pregnancy: biochemical predictors of adverse perinatal outcomes.
10.1007/s11596-013-1133-8
- Author:
Hui CHEN
1
;
Yuan ZHOU
;
Dong-rui DENG
;
Hai-yan HAO
;
Jing DANG
;
Jing LI
Author Information
1. Department of Obstetrics and Gynecology, Tongji Hosptial, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. 125044677@qq.com
- Publication Type:Journal Article
- MeSH:
Abortion, Induced;
Adult;
Bile Acids and Salts;
analysis;
Biomarkers;
metabolism;
China;
Cholestasis, Intrahepatic;
diagnosis;
metabolism;
Female;
Humans;
Pregnancy;
Pregnancy Complications;
diagnosis;
metabolism;
Prognosis;
Reproducibility of Results;
Risk Assessment;
Sensitivity and Specificity;
Stillbirth;
Thiobarbituric Acid Reactive Substances;
analysis;
Young Adult
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2013;33(3):412-417
- CountryChina
- Language:English
-
Abstract:
This study aimed to identify biochemical predictors of adverse perinatal outcomes in intrahepatic cholestasis of pregnancy (ICP). A total of 106 ICP cases were analyzed retrospectively by the combination of receiver operating characteristic curve and binary logistic regression analysis. "Adverse perinatal outcomes" included spontaneous preterm labor, meconium-staining of amniotic fluid, stillbirth and Apgar score ≤7 at 1 or 5 min. Total bile acid (TBA) [AUC=0.658, 95%CI (0.536, 0.781), P=0.031] was a valuable predictor for adverse perinatal outcomes. The critical value of TBA above which adverse perinatal outcomes were observed was 40.15 μmol/L (Youden's index=0.3). Binary multivariate logistic regression analysis revealed that the risk of adverse perinatal outcomes increased when TBA ≥40.15 μmol/L [OR=3.792, 95%CI (1.226, 11.727), P=0.021]. It is concluded that the risk of adverse perinatal outcomes in ICP increases when maternal TBA ≥40.15 μmol/L.
