Volume regulated anion channel and ischemia/reperfusion injury of myocardium.
- Author:
Ping LI
1
;
Xiaoli SUN
Author Information
1. Department of Emergency, China-Japan Union Hospital, Jilin University, Changchun 130033, China.
- Publication Type:Journal Article
- MeSH:
Chloride Channels;
classification;
metabolism;
physiology;
Humans;
Myocardial Reperfusion Injury;
metabolism
- From:
Journal of Biomedical Engineering
2008;25(4):980-983
- CountryChina
- Language:Chinese
-
Abstract:
It has been shown that a lot of diseases were related with the change or loss of Cl- channel functions. Among the Cl- channels, volume-regulated anion channel (VRAC) plays important roles in myocardial ischemia/reperfusion injury, cardiac arrhythmia and apoptosis; it may become a new target in the clinical treatment of heart diseases. This paper presents an overview of the physiological characteristics of VRAC and its relations with myocardial ischemia/reperfusion injury.
