The effect of a simulated inflammation procedure in simulated body fluid on bone-like apatite formation on porous HA/beta-TCP bioceramics.
- Author:
Jingou JI
1
;
Junguo RAN
;
Li GOU
;
Fangfu WANG
;
Luwei SUN
Author Information
1. Department of Inorganic Materials, Sichuan University, Chengdu 610065, China.
- Publication Type:Journal Article
- MeSH:
Apatites;
chemistry;
Biocompatible Materials;
chemistry;
Body Fluids;
chemistry;
Bone Cements;
chemistry;
Bone Substitutes;
chemistry;
Calcium Phosphates;
chemistry;
Ceramics;
Hydroxyapatites;
chemistry;
Inflammation;
Materials Testing;
methods;
Microwaves;
Osseointegration;
Porosity;
Surface Properties
- From:
Journal of Biomedical Engineering
2004;21(4):531-535
- CountryChina
- Language:Chinese
-
Abstract:
The formation of bone-like apatite on porous HA/beta-TCP bioceramics in dynamic simulated body fluid (SBF) undergoing a simulated inflammation procedure (pH = 6.5) was investigated in order to study the mechanism of osteoinduction and build a new method to choose biomaterials with better bioactivity. The results showed that the surface of porous HA/beta-TCP bioceramics which underwent a simulated inflammation procedure in dynamic SBF was more smooth. The light acidity in the simulated inflammation procedure would dissolve the fine grains and the parts possessing smaller curvature radius on the surface of porous HA/beta-TCP bioceramics, which would reduce the bioceramics solubility. Followed in normal SBF (pH = 7.4), the amount of bone-like apatite formed on the porous HA/beta-TCP bioceramics was less than that of porous HA/beta-TCP bioceramics incubation in normal SBF all along. The results also showed that the amount of bone-like apatite formed on the porous HA/beta-TCP bioceramics sintered by a microwave plasma was more than that of porous HA/beta-TCP bioceramics sintered by a conventional furnace.
