The Effect of Mosapride on Quality of Life in Functional Dyspepsia.
- Author:
Yu Kyung CHO
1
;
Myung Gyu CHOI
;
Se Hee KIM
;
In Seok LEE
;
Sang Woo KIM
;
In Sik CHUNG
;
Sang Yeol LEE
;
Suck Chei CHOI
;
Sang Young SEOL
Author Information
1. Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea. choim@catholic.ac.kr
- Publication Type:Original Article ; Clinical Trial ; English Abstract
- Keywords:
Nepean dyspepsia index-Korean version;
Mosapride;
Quality of life;
Functional dyspepsia
- MeSH:
Adult;
Aged;
Benzamides/*therapeutic use;
Dopamine Antagonists/*therapeutic use;
Dyspepsia/diagnosis/*drug therapy;
English Abstract;
Female;
Gastrointestinal Agents/*therapeutic use;
Humans;
Male;
Middle Aged;
Morpholines/*therapeutic use;
*Quality of Life;
Questionnaires
- From:The Korean Journal of Gastroenterology
2004;43(3):160-167
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: It is unknown whether the prokinetics improve the quality of life in patients with functional dyspepsia. Thus, we evaluate the effect of the mosapride, selective 5-HT4 agonist, on the symptom and life quality of patients with functional dyspepsia using the Nepean dyspepsia index-Korean version (NDI-K), a reliable and validated disease-specific quality of life questionnaire. METHODS: A single, open trial was performed in 129 patients with functional dyspepsia. Patients were received mosapride 5 mg t.i.d before each meal for 4 weeks. The symptoms and quality of life were measured with the NDI-K at baseline and 4 weeks. The responsiveness of the NDI-K was evaluated by correlation with symptom scores. RESULTS: All the 15 symptom scores and the dyspepsia score decreased after treatment (p<0.05). The total symptom score decreased from 60.9 +/- 25.8 to 24.7 +/- 20.4 (p=0.001). Correlations were observed between the total symptom score and the NDI-K score (r=0.47, p=0.001), and between the total symptom score and each score in 5 subscales (r=0.25-0.44, p=0.001). The NDI-K score was significantly increased in the effective group whose dyspepsia score decreased more than 50% of the score at baseline, compared with that of ineffective group. Any significant adverse effect and prolongation of QT interval were not occurred in all patients. CONCLUSIONS: A prokinetic drug, mosapride improves the symptoms and the quality of life in patients with functional dyspepsia.
