Quick and simultaneous dosage of benzoic acid and salicylic acid in the ointment "Benzosali" by high performance Liquid Chrommataraphy (HPLC)
- Author:
Nga Viet Pham
- Publication Type:Journal Article
- Keywords:
Benzoic acid
- MeSH:
Ointments;
benzoic acid;
salicylic acid
- From:Pharmaceutical Journal
1999;282(10):19-21
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
An HPLC method was proposed to determine rapidly and simultaneously benzoic acid and salicylic acid in the benzosali ointment. The chromatographic conditions were: column lichrosorb RP 18 (25x4x10), mobile phase: methanol - 0.017 M, postassiumdihydrophosphat solution - 12.5%, tetrabutylamonium hydroxide solution (400: 800: 1.5 V/V/V) at flow rate 1-1.5ml min-1 and the detection at 230nm. Experimental results proved that the proposed HPLC method was simple, stable, accurate and precise.
