In-vitro evaluation of haemocompatibility of biomaterials.
- Author:
Jianxia XU
1
;
Chunren WANG
;
Tingfei XI
Author Information
1. National Institute for Control of Pharmaceutical and Biological Products, Beijing 100050, China.
- Publication Type:Journal Article
- MeSH:
Biocompatible Materials;
Evaluation Studies as Topic;
Humans;
Materials Testing;
standards
- From:
Journal of Biomedical Engineering
2004;21(5):861-870
- CountryChina
- Language:Chinese
-
Abstract:
In-vitro test is usually conducted as a preliminary screening test in the evaluation of the haemocompatibility of biomaterials for its short-term consuming, convenience and less expense. The selection of appropriate model for blood-biomaterial interaction, the choice of sensitive and specific parameters, and the minimization of additional blood activation are most important in the in-vitro test. In addition, the time and the style of blood-biomaterial interaction, the choice of sensitive and specific parameters, and the minimization of additional blood activation are most important in the in-vitro test. In addition, the time and the style of blood-biomaterial interaction, the selection of primary reference materials and the shear rate should be considered. In recent years, though great progress has been made in the in-vitro evaluation of haemocompatibility of biomaterials, all these influencing factor should be standardized for more effective evaluation of the haemocompatibility of biomaterials.
