Inhibitory effect of electrochemotherapy on S180 tumor growth and angiogenesis and the possible mechanism.
- Author:
Fangdong ZOU
1
;
Hong LI
;
Zishu WANG
;
Bisong YUE
;
Qin GENG
;
Baoyi WANG
Author Information
1. College of Life Science, Sichuan University, Chengdu 610064, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Antimetabolites, Antineoplastic;
administration & dosage;
Bleomycin;
administration & dosage;
Combined Modality Therapy;
Electric Stimulation Therapy;
methods;
Electrochemistry;
Mice;
Neovascularization, Pathologic;
prevention & control;
Sarcoma 180;
blood supply;
therapy
- From:
Journal of Biomedical Engineering
2004;21(6):888-892
- CountryChina
- Language:Chinese
-
Abstract:
This study evaluated the effects of electric pulses combined with antitumor drugs on S180 tumor cells. It was found that the growth of S180 sarcoma was inhibited with a maximum inhibition ratio of 95.5% after the use of electric pulses in combination with the injection of bleomycin (BLM), and the blood vessels of tumor were obviously fewer than those of the untreated tumor in vivo. The mitochondria of S180 tumor cells were swollen after the use of electric pulses in combination with adriamycin. The results showed that electrochemotherapy has evident inhibitory effect on the growth of S180 sarcoma and the mechanism may involve the suppression of tumor angiogenesis and changes in the ultrastructures of tumor cells.
