Preparation and degradation behavior of PELGE nanoparticles.
- Author:
Yourong DUAN
1
;
Zhirong ZHANG
;
Yonggang TANG
;
Yunzhu LIN
Author Information
1. West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
- Publication Type:Journal Article
- MeSH:
Biocompatible Materials;
chemistry;
Biodegradation, Environmental;
Drug Carriers;
Drug Delivery Systems;
Humans;
Lactic Acid;
chemical synthesis;
chemistry;
Microspheres;
Nanostructures;
Nanotechnology;
Polyesters;
chemical synthesis;
chemistry;
Polyethylene Glycols;
chemical synthesis;
chemistry;
Polyglactin 910;
chemistry;
Polyglycolic Acid;
chemical synthesis;
chemistry;
Polymers;
chemical synthesis;
chemistry
- From:
Journal of Biomedical Engineering
2004;21(6):921-925
- CountryChina
- Language:Chinese
-
Abstract:
A series of poly (lacticacid-co-glycolicacid)-poly(ethylene glycol) (PLGA-PEG, PELGA) block copolymers and poly (ethylene glycol)-poly (lacticacid-co-glycolicacid)-poly (ethylene-glycol) (PELGE) was synthesized by ring-opening polymerization. PELGA nanoparticles and PELGE nanoparticles were prepared using the emulsion-solvent evaporation technique (O/W). To study the behavior and mechanism of the degradation of PELGA-NP and PELGA-NP, we determined the lactic acids by UV spectrophotometry. The method confirmed that degradation was much faster for polymers with a decrease in the LA content of the polymers or an increase in the PEG content of the polymers.
