Human Herpes Virus-6 Meningoencephalitis Following Allogeneic Hematopoietic Stem Cell Transplantation.
- Author:
Dong Gun LEE
1
;
Yoo Jin KIM
;
Jung Hyun CHOI
;
Wan Shik SHIN
;
Sang Tae PARK
;
Dong Kyun SON
;
Dong Wook KIM
;
Woo Sung MIN
;
Chun Choo KIM
Author Information
1. Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea. fire@cmc.cuk.ac.kr
- Publication Type:Case Report
- Keywords:
Herpesvirus 6;
Human;
Encephalitis;
viral;
Bone marrow transplantation
- MeSH:
Bone Marrow Transplantation;
Cerebrospinal Fluid;
DNA;
Encephalitis;
Exanthema;
Fever;
Hematopoietic Stem Cell Transplantation*;
Hematopoietic Stem Cells*;
Herpesvirus 4, Human;
Herpesvirus 6, Human;
Humans*;
Meningoencephalitis*;
Multiplex Polymerase Chain Reaction
- From:Korean Journal of Infectious Diseases
2001;33(6):448-452
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Two cases of human herpesvirus-6 (HHV-6) encephalitis that occurred after allogeneic hematopoietic stem cell transplant (HSCT) are presented. Both patients reported fever, skin rashes, and neurological symptoms, characterized by disorientation, confusion and drowsy mental status. HHV-6B DNA was detected from the cerebrospinal fluid (CSF) specimens by a multiplex polymerase chain reaction (PCR) assay including EBV, CMV, HHV-6B. After treatment with intravenous gan ciclovir for 2~3 weeks, all clinical manifestations were resolved and the HHV-6B DNA was cleared from the CSF in both patients. HHV-6 should be considered as a possible cause of neurological symptoms after HSCT, and prompt antiviral treatment should be begun.
