Autophagy and caveolin-1 in cancer: a review.
- Author:
Yan LIU
1
;
Yang WANG
;
Dan SHI
;
Wei ZOU
Author Information
1. College of Life Sciences, Liaoning Normal University, Dalian 116081, Liaoning, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Autophagy;
physiology;
Caveolin 1;
physiology;
Humans;
Neoplasms;
pathology;
physiopathology
- From:
Chinese Journal of Biotechnology
2012;28(8):912-917
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy, is an essential cellular process involving self-degradation of intracellular components via the lysosome, which plays the Janus role in cancer initiation and progression. Caveolin-1, a marker protein of caveolae, functions as scaffolding protein mediating many physiological and pathological processes including caveolae biogenensis, vesicular transport, cholesterol homeostasis, signal transduction and tumorigenesis. Recently, many reports showed that autophagy of tumor cells associated with stromal Cav-1. We reviewed that the relationship between autophagy and Cav-1 involved in tumorigenesis and development.
