Microbial production of chondroitin sulfate: a review.
- Author:
Qiulin WU
1
;
Liming LIU
;
Jian CHEN
Author Information
1. State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu, China.
- Publication Type:Journal Article
- MeSH:
Bacillus subtilis;
metabolism;
Bacteria;
genetics;
metabolism;
Chondroitin Sulfates;
biosynthesis;
Escherichia coli;
metabolism;
Fermentation;
Genetic Engineering;
Industrial Microbiology;
Pasteurella multocida;
metabolism
- From:
Chinese Journal of Biotechnology
2012;28(11):1281-1293
- CountryChina
- Language:Chinese
-
Abstract:
Chondroitin sulfate (CS) is the typical sulfation glycosaminoglycan and widely applied in the industries of pharmaceutical, health products and cosmetic for its peculiar properties. CS is the main component of cartilage proteoglycans in animal and capsular polysaccharide in a few bacteria. CS can be extracted from animal sources and produced via microbial fermentation. In this article, development of chondroitin sulfate by fermentation, biosynthesis and regulating mechanisms of CS in bacteria are described. Furthermore, prospect and tendency of chondroitin sulfate from bacterial fermentation are addressed.
