Being Overweight or Obese Increases the Risk of Progression in Triple-Negative Breast Cancer after Surgical Resection.
10.3346/jkms.2016.31.6.886
- Author:
Yunseon CHOI
1
;
Sung Kwang PARK
;
Ki Jung AHN
;
Heunglae CHO
;
Tae Hyun KIM
;
Hye Kyoung YOON
;
Yun Han LEE
Author Information
1. Department of Radiation Oncology, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea. rtyoon@gmail.com
- Publication Type:Original Article
- Keywords:
Triple-Negative Breast Cancer;
Overweight;
Obesity;
Body Mass Index;
Prognosis
- MeSH:
Adult;
Aged;
Body Mass Index;
Disease Progression;
Disease-Free Survival;
Female;
Follow-Up Studies;
Humans;
Middle Aged;
Neoplasm Recurrence, Local;
Obesity/*complications;
Overweight/*complications;
Prognosis;
Retrospective Studies;
Risk Factors;
Survival Rate;
Triple Negative Breast Neoplasms/*complications/mortality/*pathology
- From:Journal of Korean Medical Science
2016;31(6):886-891
- CountryRepublic of Korea
- Language:English
-
Abstract:
This study aimed to evaluate the association between body mass index (BMI) and progression in triple-negative breast cancer (TNBC). We retrospectively reviewed the medical records of 50 patients with TNBC who underwent breast-conserving surgery or mastectomy between 2007 and 2014. All patients were classified according to BMI (median 23.5 kg/m2, range 17.2-31.6 kg/m2): 31 patients (62%) were classified as being overweight or obese (BMI ≥ 23 kg/m2) and 19 patients (38%) were classified as having a normal body weight (BMI < 23 kg/m2). The median follow-up for patients was 31.1 months (range, 6.7-101.9 months). Progression occurred in 7 patients (14%), including 5 ipsilateral breast tumor recurrences, 2 regional lymph node metastases, and 5 distant metastases. Progression was significantly correlated with overweight or obese patients (P = 0.035), while none of the normal weight patients showed progression. The 3-year disease-free survival (DFS) and overall survival (OS) rates were 85.0% and 87.7%, respectively. DFS was significantly reduced in overweight or obese patients compared to that in normal weight patients (P = 0.035). However, OS was not significantly compromised by being overweight or obese (P = 0.134). In conclusion, being overweight or obese negatively affects DFS in TNBC patients.
