Study on the association of PPP1R3 gene polymorphism with type 2 diabetes in Han population of Anhui province.
- Author:
Ming-Wei CHEN
1
;
Ming-Gong YANG
;
Chang-Jiang WANG
;
You-Min WANG
;
Xi-Ping XU
;
Shu-Qin LIU
;
Qiu ZHANG
;
Hai-Yan SUN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Alleles; Aspartic Acid; genetics; China; epidemiology; ethnology; Diabetes Mellitus, Type 2; epidemiology; etiology; genetics; Female; Gene Frequency; Genotype; Humans; Male; Middle Aged; Obesity; complications; Phosphoprotein Phosphatases; genetics; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Protein Phosphatase 1; Risk Factors; Tyrosine; genetics
- From: Chinese Journal of Epidemiology 2004;25(6):534-536
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the association of muscle-specific glycogen-targeting regulatory subunit of the glucogen-bound protein phosphatase 1 (PPP1R3) gene codon 905 Asp/Tyr polymorphism with type 2 diabetes in Chinese Han population in Hefei region of Anhui province.
METHODSPPP1R3 gene Asp905Tyr polymorphism was detected by polymerase chain reaction and appropriate restriction enzyme (PCR-RFLP) in 262 type 2 diabetic cases and 104 normal controls. Case and control groups were divided into subgroups by body mass index (BMI) 25 kg/m2.
RESULTSWhen PPP1R3 gene Asp905Tyr polymorphism was not associated with type 2 diabetes mellitus. When subjects with BMI < 25 kg/m2 and Tyr/Tyr genotypes were used as reference. Subjects with Asp905 and BMI > or = 25 kg/m2 had a 3.69-fold increase of risk suffering from type 2 diabetes (OR = 3.69, 95% CI: 1.38-8.89, P=0.006).
CONCLUSIONSPPP1R3 gene Asp905Tyr polymorphism did not seem to play a critical role in the development of type 2 diabetes mellitus in Han population of Chinese in Anhui province but interaction between the Asp905 and BMI cause the increase of risk of type 2 diabetes.
