Postmarketing surveillance on Benazepril.
- Author:
Jun LU
1
;
Li-ming LI
;
Wei-hua CAO
;
Si-yan ZHAN
;
Yong-hua HU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; adverse effects; therapeutic use; Benzazepines; adverse effects; therapeutic use; China; epidemiology; Cough; chemically induced; epidemiology; Female; Humans; Hypertension; drug therapy; epidemiology; Male; Middle Aged; Product Surveillance, Postmarketing
- From: Chinese Journal of Epidemiology 2004;25(5):412-416
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the long-term effect, safety and tolerability of benazepril in general hypertensive patients.
METHODSWe conducted a three-year community-based postmarketing surveillance on benazepril among 1831 essential hypertensive patients (age range from 35 to 88 years) in Shanghai.
RESULTS74.3% of patients persisted in medication taking and were with optimal compliance in a 3-year-follow-up program. Among those taking medication as prescribed after 3 years, 75.7% of them attained systolic blood pressure (SBP) target level of 140 mm Hg (1 mm Hg = 0.133 kPa), 87.4% attained diastolic blood pressure (DBP) target level of 90 mm Hg, and 71.5% attained total target level of 140/90 mm Hg. The reductions were approaching 15 mm Hg for SBP, 10 mm Hg for DBP, and 5 mm Hg for pulse pressure (PP) during the 3 year period. No serious adverse drug reactions (ADRs) were detected during the 3 years follow-up. Cough was the most common ADR. The cumulative incidence of benazepril related cough was 23.6% in women, significant higher than in men (18.8%).
CONCLUSIONBenazepril was safe and tolerable when applied in hypertensive patients.
