Thrombosis and morphology of plaque rupture using optical coherence tomography.
- Author:
Jun GUO
1
;
Yun-Dai CHEN
;
Feng TIAN
;
Hong-Bin LIU
;
Lian CHEN
;
Zhi-Jun SUN
;
Yi-Hong REN
;
Qin-Hua JIN
;
Chang-Fu LIU
;
Bao-Shi HAN
;
Lu-Yue GAI
;
Ting-Shu YANG
Author Information
- Publication Type:Journal Article
- MeSH: Acute Coronary Syndrome; diagnostic imaging; etiology; Adult; Aged; Coronary Angiography; Female; Humans; Male; Middle Aged; Plaque, Atherosclerotic; complications; diagnostic imaging; Rupture, Spontaneous; complications; Tomography, Optical Coherence; methods
- From: Chinese Medical Journal 2013;126(6):1092-1095
- CountryChina
- Language:English
-
Abstract:
BACKGROUNDThrombosis following plaque rupture is the main cause of acute coronary syndrome, but not all plaque ruptures lead to thrombosis. There are limited in vivo data on the relationship between the morphology of ruptured plaque and thrombosis.
METHODSWe used optical coherence tomography (OCT) to investigate the morphology of plaque rupture and its relation to coronary artery thrombosis in patients with coronary heart disease. Forty-two patients with coronary artery plaque rupture detected by OCT were divided into two groups (with or without thrombus) and the morphological characteristics of ruptured plaque, including fibrous cap thickness and broken cap site, were recorded.
RESULTSThe fibrous cap of ruptured plaque with thrombus was significantly thinner compared to caps without thrombus ((57.00 ± 17.00) µm vs. (96.00 ± 48.00) µm; P = 0.0076).
CONCLUSIONSPlaque rupture associated with thrombosis occurs primarily in plaque covered by a thin fibrous cap. Thick fibrous caps are associated with greater stability of ruptured plaque.
