Clinical analysis of infectious complications following abdominal cluster transplantation.
- Author:
Hui-xing CHEN
1
;
Lu YIN
;
Cheng-hong PENG
;
Guang-wen ZHOU
;
Bai-yong SHEN
;
Gui-ming CHEN
;
Chun-qiu CHEN
;
Hui-jiang ZHOU
;
Hong-wei LI
Author Information
- Publication Type:Case Reports
- MeSH: Adult; Bacterial Infections; drug therapy; etiology; Cytomegalovirus Infections; drug therapy; etiology; virology; Fatal Outcome; Female; Humans; Immunosuppressive Agents; adverse effects; therapeutic use; Intestine, Small; transplantation; Liver Transplantation; adverse effects; methods; Male; Opportunistic Infections; drug therapy; etiology; Organ Transplantation; adverse effects; methods; Postoperative Complications; drug therapy; etiology; Retrospective Studies
- From: Chinese Journal of Surgery 2007;45(5):319-322
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the characteristic and management of postoperative infection in abdominal cluster transplantation.
METHODSPreliminary experience of two cases of abdominal cluster transplantation including small intestine was reviewed.
RESULTSCombination of five immunosuppressive agents based on tacrolimus was used. Severe Gram-negative bacillus infections occurred. The majority of invasive fungal infections was due to Candida species. Cytomegalovirus (CMV) infection increased monocytes and caused eosinopenia and an inversion of the CD4(+) to CD8(+) cell ratio in recipient I, and human CMV matrix proteins pp71 (CMV-pp71) was detected and identified in bile by PCR. Microabscesses in liver transplant biopsies were presented.
CONCLUSIONSInfectious complications after cluster transplantation were complicated. Strategies to optimize the immunity suppression protocol and early diagnosis and treatment will be important to reduce infection after abdominal cluster transplantation.
