Expression of c-myc mRNA on early restenosis after carotid endarterectomy.
- Author:
Chun-yang LIANG
1
;
Ding-biao ZHOU
;
Xin-guang YU
;
Bai-nan XU
;
Wen-bin ZHANG
;
Shi-bo WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Carotid Arteries; metabolism; pathology; surgery; Carotid Artery Diseases; surgery; Carotid Stenosis; etiology; genetics; physiopathology; Disease Models, Animal; Endarterectomy, Carotid; adverse effects; methods; Gene Expression; Male; Postoperative Complications; etiology; metabolism; physiopathology; Proto-Oncogene Proteins c-myc; genetics; RNA, Messenger; genetics; metabolism; Rabbits; Random Allocation; Reverse Transcriptase Polymerase Chain Reaction
- From: Chinese Journal of Surgery 2007;45(8):555-557
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the expression and changes of protooncogene c-myc in early restenosis after carotid endarterectomy (CEA).
METHODSUsing New Zealand Rabbits, carotid atherosclerotic stenosis (CASS) model were created. The expression of c-myc in early restenosis after CEA were detected by quantitative real-time polymerase chain reaction (qRT-PCR).
RESULTSIn this experiment protooncogene c-myc was analysed at pre-operation, 4 hours and 1 d after CEA by qRT-PCR, and the level of mRNA of c-myc was reached maximum at 4 hours, and decreased following significantly, but still higher than pre-operation.
CONCLUSIONSThe activation of protooncogene c-myc may be generator factor of vascular smooth muscle cell proliferation.
