Anti-LW Showing Anti-D Mimicking Specificity: A Case Report.
10.17945/kjbt.2017.28.1.77
- Author:
Sunghwan SHIN
1
;
Ji Young SEO
;
SooIn CHOI
;
Sejong CHUN
;
Duck CHO
Author Information
1. Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. duck.cho@skku.edu
- Publication Type:Case Report
- Keywords:
Anti-LW;
Dithiothreitol;
Anti-D;
RhD
- MeSH:
Antibodies;
Blood Cells;
Coombs Test;
Dithiothreitol;
Follow-Up Studies;
Humans;
Immunoglobulins;
Korea;
Lymphoma, Non-Hodgkin;
Sensitivity and Specificity*
- From:Korean Journal of Blood Transfusion
2017;28(1):77-81
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
LW antigens are expressed in higher intensities in D-positive blood cells than D-negative cells, which can result in false identification of anti-D in pretransfusion testing. Although several cases of anti-LW have been reported abroad, to the best of our knowledge, none have been reported in Korea. Herein, we report a case of anti-LW in a 58 year-old RhD positive patient with non-Hodgkin's lymphoma with a positive direct Coombs test and a suspicion of the presence of passive anti-D antibodies because of a history of intravenous immunoglobulin administration. However, during a 5-month follow up, the antibody was confirmed as anti-LW on grounds that it showed weakened reaction in dithiothreitol treated cells and enforced reaction in cord O+ cells when compared to the results from antibody identification panel cells.
