Improved method of fluvoxamine synthesis.
- Author:
Tao LIU
1
;
Rong SHENG
;
Yong-zhou HU
Author Information
- Publication Type:Journal Article
- MeSH: Fluvoxamine; chemical synthesis; Serotonin Uptake Inhibitors; chemical synthesis
- From: Journal of Zhejiang University. Medical sciences 2003;32(5):441-442
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo modify the synthetic method of fluvoxamine.
METHODSFluvoxamine was synthesized from 4-trifluoromethylbenzonitrile by the steps of Grignard reaction, hydrolysis and oximation.
RESULTThe chemical structure of the synthesized product was confirmed by (1)HNMR, and the total yield reached to 36.16%.
CONCLUSIONThe results indicate that the synthetic route is practical.
