Experimental study on attachment of bacillus Calmette-Guerin to bladder wall with different types of injury.
- Author:
Guo-qing DING
1
;
Zhou-jun SHEN
;
Zhao-dian CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Bacterial Adhesion; Female; Male; Mycobacterium bovis; physiology; Rabbits; Urinary Bladder; injuries; microbiology
- From: Journal of Zhejiang University. Medical sciences 2004;33(1):65-67
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate whether different types of injury on bladder wall can influence bacillus Calmette-Guerin (BCG) attachment.
METHODSThe bladder mucosa of 24 rabbits were treated by electrocautery,cryocautery and incision on left lateral wall, right lateral wall and posterior wall, respectively. Then radiolabeled BCG ((3)H-BCG) was instilled into bladder. Two hours latter, the injured bladder wall with different methods and non-injured wall (anterior wall of bladder) were surgically removed and digested. The quantity of BCG of each specimen was determined by liquid scintillation counter.
RESULTThe quantity of BCG attachment to bladder wall with different injuries was significantly higher than that of non-injured wall (P<0.001), meanwhile there was no statistically difference among the BCG levels of different injury types (P>0.05).
CONCLUSIONBCG attachment is not influenced by different types of injury on the bladder wall.
