An improved novel method of venlafaxine synthesis.
- Author:
Rong SHENG
1
;
Tao LIU
;
Yong-zhou HU
Author Information
- Publication Type:Journal Article
- MeSH: Antidepressive Agents, Second-Generation; chemical synthesis; Cyclohexanols; chemical synthesis; Venlafaxine Hydrochloride
- From: Journal of Zhejiang University. Medical sciences 2004;33(1):77-79
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo synthesize venlafaxine with an improved novel method.
METHODSp-methoxypheny lethyl-acid was reacted with SOCl(2) to produce acyl chloride which was reacted with N,N-dimethylamine solution to get amide; then through Ivanov reaction and reduction by KBH(4)/BF(3).Et(2)O to yield venlafaxine.
RESULTVenlafaxine was successfully synthesized by using this method with an yield rate of 50.3%.
CONCLUSIONThe improved method is suitable for industrial production of venlafaxine.
