A possible preneoplastic lesion of colorectum.

Author: Mao-de LAI ¹ ; Qiong HUANG ; Reza PARWARESCH
Author Information

1. Department of Pathology and Pathophysiology, Center for Environmental Genomics, College of Medicine, Zhejiang University, Hangzhou 310031, China. lmp@zju.edu.cn
Publication Type:Journal Article
MeSH: Adult; Aged; Aged, 80 and over; Antigens, Nuclear; analysis; Biomarkers, Tumor; analysis; Colorectal Neoplasms; pathology; Female; Humans; Immunohistochemistry; Male; Middle Aged; Precancerous Conditions; pathology
From: Journal of Zhejiang University. Medical sciences 2004;33(2):115-117
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo investigate KiA10 expression in colorectal cancer and related colorectal tissues.
METHODSKiA10 expression was detected by immunohistochemistry in tissue specimens from 101 cases of colorectal cancer and matched cut-margin mucosa and mucosa adjacent to cancers; also in colorectal specimens from 16 cases of ulcerative colitis, 16 of Crohn's disease and 3 healthy subjects.
RESULTThe positive rate of KiA10 expression in colorectal cancer was 14.85% (15/101); KiA10 positive crypts was demonstrated in 18 cut-margin mucosa and 18 mucosa adjacent to tumors respectively, but they were not matched with each other.
CONCLUSIONThe results suggest that KiA10-positive crypts of the colon might be a preneoplastic lesion.