Growth-suppression effect of hydroxyurea on meningioma cells in vitro.
- Author:
Shu-xu YANG
1
;
Yi-rong WANG
;
Hai-peng GAN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Apoptosis; drug effects; Cell Division; drug effects; Cell Line, Tumor; Dose-Response Relationship, Drug; Female; Flow Cytometry; Humans; Hydroxyurea; pharmacology; Male; Meningioma; drug therapy; pathology; Middle Aged
- From: Journal of Zhejiang University. Medical sciences 2004;33(2):129-132
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the tumor-suppression effect of hydroxyurea on meningioma cells and its possible mechanism.
METHODSThe meningioma cells were cultured in medium containing varied doses of hydroxyurea (5x10(-3)mol/L, 5x10(-4)mol/L, 5x10(-5)mol/L), the cell growth was measured by MTT method, cell apoptosis was observed with flow cytometry (FCM).
RESULTSMTT measurement demonstrated that the administration of hydroxyurea led to a dose-dependent suppression in cell proliferation and FCM showed a dose-dependent increase in apoptosis rate.
CONCLUSIONHydroxyurea can inhibit meningioma cell growth in vitro, which is most likely associated with apoptosis of the tumor cells.
