Mechanisms of pethidine-induced vasodilatation.
- Author:
Xiong ZHANG
1
;
Ling-ying CHAI
;
Xiao-mei TONG
;
Yuan LU
;
Qiang XIA
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Caffeine; pharmacology; Calcium; metabolism; Male; Meperidine; pharmacology; Potassium Chloride; pharmacology; Rats; Rats, Sprague-Dawley; Vasodilator Agents; pharmacology
- From: Journal of Zhejiang University. Medical sciences 2004;33(2):166-169
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the vasodilating effects of pethidine, particularly in association with intracellular calcium.
METHODSAorta rings of Sprague-Dawley rats, with or without endothelium, were prepared in organ bath to measure the vascular tone. Pre-contractions by KCl (80 mmol/L) and phenylephrine (PhE) (10(-6)mol/L) were induced.
RESULTSPethidine did not alter the resting tension of aorta rings, but produced dose-dependent relaxation in KCl and PhE pre-treated aorta rings with or without endothelium. Pethidine did not change the caffeine-stimulated contraction, and still had similar inhibition in KCl pre-contracted aorta rings after pretreatment with ruthenium red. Pethidine decreased the contractile responses induced by PhE in Ca(2+)-free solution or by adding calcium into Ca(2+)-free solution.
CONCLUSIONPethidine could produce an endothelium-independent vasodilatation in KCl and PhE pre-contracted aorta rings, which is related to inhibition of Ca(2+)entry and IP3-sensitive Ca(2+) release in vascular smooth muscle.