Mechanisms of the effect of brain histamine on chronic epilepsy induced by pentylenetetrazole.
- Author:
Li-san ZHANG
1
;
Hai-qing SHEN
;
Chun-lei JIN
;
Wei-wei HU
;
Meng-hui ZHAO
;
Zhong CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Brain; physiology; Chronic Disease; Dose-Response Relationship, Drug; Epilepsy; chemically induced; Histamine; physiology; Histidine; pharmacology; Imidazoles; pharmacology; Male; Pentylenetetrazole; pharmacology; Piperidines; pharmacology; Rats; Rats, Sprague-Dawley; Thiourea; analogs & derivatives; pharmacology
- From: Journal of Zhejiang University. Medical sciences 2004;33(3):201-204
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the mechanisms of histamine on chronic epilepsy induced by pentylenetetrazole (PTZ).
METHODSTo induce chemical kindling, a subconvulsive dose (35mg/kg) of PTZ was ip injected every 48 h in rats. Behavior changes were observed for 30 min after every injection of PTZ.
RESULTIp injection of histidine or icv injection of clobenpropit inhibited the development of kindling induced by PTZ, presenting prolonged latency for myoclonic jerks and clonic generalized seizures and depressed seizure stages in a dose-dependent manner. H(3)receptor agonist, immepip, and histidine decarboxylase, alpha-fluoromethylhistidine reversed the ameliorating effect of clobenpropit on seizure development in a dose-dependent manner.
CONCLUSIONBrain histamine plays an important role in protection against myoclonic jerks and clonic generalized clonic seizures and its action may be via H(3)receptor.
