Effects between the first-and second-generation histamine H1-antagonists on seizure development of pentylenetetrazole-induced kindling in rats.
- Author:
Chun-lei JIN
1
;
Zhong CHEN
;
Li-san ZHANG
;
Yi GUO
;
Liu-yan ZHANG
;
Kazuhiko YANAI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Histamine; physiology; Histamine H1 Antagonists; pharmacology; Histamine H1 Antagonists, Non-Sedating; pharmacology; Histidine; pharmacology; Kindling, Neurologic; drug effects; Male; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; chemically induced
- From: Journal of Zhejiang University. Medical sciences 2004;33(3):209-212
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effects and the mechanisms of the first-generation histamine H(1)-antagonist diphenhydramine and the second-generation histamine H(1)- antagonist fexofenadine on seizure development of pentylenetetrazole (PTZ)-induced kindling in rats.
METHODSThe first-or second-generation histamine H(1)-antagonists and/or histidine were ip injected in rats every 48 h, followed by a subconvulsive dose of PTZ (35 mg/kg). Then the behavioral changes were observed for 30 min after every injection of PTZ. The histamine content of brain was measured spectrofluorometrically.
RESULTCompared with the control group, diphenhydramine (5 mg/kg) significantly augmented the severity of seizure development of PTZ-induced kindling, whereas fexofenadine (5 mg/kg) had no marked influence. The effects of diphenhydramine were antagonized by histidine, the precursor of histamine.
CONCLUSIONSeizure development of PTZ-induced kindling is promoted by the first-but not the second generation histamine H(1)-antagonists via the blockade of brain histamine H(1)-receptor.
