Investigation on release model of insoluble drug in hydroxypropyl methycellulose matrix tablets.
- Author:
Xiao-wei MA
1
;
Jing-qun YUAN
;
Wen-quan LIANG
Author Information
- Publication Type:Journal Article
- MeSH: Carbamazepine; administration & dosage; chemistry; Delayed-Action Preparations; Hypromellose Derivatives; Methylcellulose; administration & dosage; analogs & derivatives; Models, Theoretical; Solubility; Tablets
- From: Journal of Zhejiang University. Medical sciences 2004;33(3):225-228
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the release model of insoluble drug carbamazepine (CBM) based on HPMC matrix tablets.
METHODSCBM release profile from matrices and HPMC erosion rate were determined.
RESULTThe mathematical model by matrix erosion rate and drug release from HPMC K15M were established for the fractional HPMC and CBM released as M(P(t))/M(P(infinity))=-[0.8095ln((t))+1.2775]Meq((-0.0622t-0.305)) and M(d(t))/M(d(infinity))=-[0.1891t-0.1294]Meq(-0.9326). In comparison with the data of HPMC K4M matrix erosion and CBM release from HPMC K4M matrices, theoretical value agreed well with experimental data.
CONCLUSIONThe two mathematical models can be satisfactorily applied to insoluble drug release, which is governed by matrix erosion.
