Correlations between micromeritic properties of mixing powders of danshen extract and formability of their pellets.
- Author:
Zhi-wei XTONG
;
Yun LUO
;
Zheng-gen LIAO
;
Guo-wei ZHAO
;
Zhe LI
;
Juan LUO
- Publication Type:Journal Article
- MeSH:
Cellulose;
chemistry;
Drug Compounding;
methods;
Drug Implants;
chemistry;
Drugs, Chinese Herbal;
chemistry;
Excipients;
chemistry;
Lactose;
chemistry;
Medicine, Chinese Traditional;
methods;
Particle Size;
Powders;
chemistry;
Starch;
chemistry
- From:
China Journal of Chinese Materia Medica
2014;39(22):4317-4323
- CountryChina
- Language:Chinese
-
Abstract:
It was difficult to prepare traditional Chinese medicine pellets due to the adverse characteristics of the herbal extract. In this study, Danshen extract (DS) powder mixed with different proportions of microcrystalline cellulose (MCC), lactose and starch were made into pellets by extrusion-spheronization. Particle size, span, bulk density, tapping density, compressibility, Hausner ratio and angle of repose were used to evaluate the micromeritic properties of mixing powders. Feret diameter, aspect ratio, yield, density and friability were used to evaluate the properties of the pellets. The correlations between micromeritic properties of raw material powders and the formability of their pellets were analyzed by cluster analysis, principal component analysis and partial least squares regression analysis. As a result, the particle size of the powders was negatively correlated with the size, density, yield, and was positively correlated with the friability of their pellets. The span, density, compressibility and angle of repose of the powders were positively correlated with the size, density, yield, and were negatively correlated with the friability of their pellets. So there were certain correlations between the micromeritic properties of raw material powders and the properties of their pellets prepared by extrusion-spheronization. This research provided a foundation for the technology and method of traditional Chinese medicine extract pellets.
