Coumarins from Leonurus japonicus and their anti-platelet aggregative activity.
- Author:
Huai YANG
;
Qin-mei ZHOU
;
Cheng PENG
;
Lu-si LIU
;
Xiao-fang XIE
;
Liang XIONG
;
Zhao-hua LIU
- Publication Type:Journal Article
- MeSH:
Blood Platelets;
drug effects;
Coumarins;
chemistry;
pharmacology;
Leonurus;
chemistry;
Platelet Aggregation;
drug effects;
Platelet Aggregation Inhibitors;
chemistry;
pharmacology
- From:
China Journal of Chinese Materia Medica
2014;39(22):4356-4359
- CountryChina
- Language:Chinese
-
Abstract:
Chemical constituents of Leonurus japonicus were isolated and purified by a combination of various chromatographic techniques including column chromatography over silica gel, Sephadex LH-20, MCI, and Rp C18. Structures of the isolates were determined by spectroscopic analysis as 10 coumarins: bergapten (1), xanthotoxin (2), isopimpinellin (3), isogosferal (4), imperatorin (5), meransin hydrate(6), isomeranzin(7), murrayone(8) , auraptenol(9), and osthol(10). In addition to compound 9, the others were isolated from the genus Leonurus for the first time. In the in vitro assay, compounds 4 and 8 significantly inhibited the abnormal increase of platelet aggregation induced by ADP.
