Phenotypic modulation of vascular smooth muscle cells in diabetes mellitus and intervention of traditional Chinese medicines.
- Author:
Xiao-dong MA
;
Zhuo-an CHEN
;
Jian-pu ZHENG
- Publication Type:Journal Article
- MeSH:
Atherosclerosis;
drug therapy;
prevention & control;
Cell Movement;
drug effects;
Cell Proliferation;
drug effects;
Diabetes Mellitus;
drug therapy;
pathology;
Drugs, Chinese Herbal;
therapeutic use;
Humans;
Hypertension;
drug therapy;
prevention & control;
Medicine, Chinese Traditional;
Muscle, Smooth, Vascular;
drug effects;
Myocytes, Smooth Muscle;
drug effects;
Phenotype
- From:
China Journal of Chinese Materia Medica
2014;39(24):4723-4727
- CountryChina
- Language:Chinese
-
Abstract:
Proliferation and migration of vascular smooth muscle cells (VSMC) are common pathological features of diabetic vascular complications,such as atherosclerosis and hypertension. Phenotypic modulation of VSMC is the basis for VSMC proliferation and migration. Therefore, studies on VSMC phenotypic modulation and its mechanisms in diabetes mellitus were of important significance to the prevention and therapy of diabetic vascular complications. This paper introduces VSMC phenotypic modulation and the underlying mechanisms in diabetes mellitus, and summarizes advance of studies on traditional Chinese medicine intervention upon VSMC phenotypic modulation, so as to provide reference for preventing and treating diabetic vascular complications with traditional Chinese medicines.
